High-Purity Recombinant Human MAN2C1 protein (N-His): A Vital Tool for Glycobiology and Oncology Research

1. Introduction

In the rapidly evolving landscape of modern biotechnology and drug discovery, the demand for precision-engineered proteins has never been greater. Recombinant Human MAN2C1 protein (N-His) stands as a critical component in the biochemical field, particularly within the specialized domains of glycobiology and cancer research. As a key enzyme involved in the catabolic pathways of free oligosaccharides, MAN2C1 represents the intersection of scientific innovation and clinical potential. Its relevance to the growth of research institutions, healthcare diagnostics, and pharmaceutical manufacturing underscores its importance as an essential building block for laboratories aiming to push the boundaries of medical science. By providing a high-fidelity tool for studying complex glycosylation patterns, this protein aligns with global efforts to advance precision medicine and sustainable biotechnological development.

2. Product Overview

MAN2C1, also known as Mannosidase Alpha Class 2C Member 1, is a cytosolic enzyme that plays a fundamental role in the degradation of N-glycans. Specifically, it is responsible for the hydrolysis of terminal alpha-D-mannose residues from free oligosaccharides released during the processing of glycoproteins. Our Recombinant Human MAN2C1 protein (N-His) is produced using advanced mammalian or insect cell expression systems to ensure proper folding and post-translational modifications that are essential for biological activity. The protein is engineered with a polyhistidine (N-His) tag at the N-terminus, which facilitates streamlined purification and highly sensitive detection in various biochemical assays. Manufactured to meet rigorous international quality benchmarks, this reagent ensures consistency and reproducibility for high-stakes laboratory environments. Each batch undergoes stringent testing for purity, concentration, and enzymatic activity, complying with the highest standards required for pharmaceutical and academic research.

3. Key Features and Benefits

• Exceptional Purity and Bioactivity: With a purity level typically exceeding 95% as determined by SDS-PAGE, this protein ensures minimal background interference and high specific activity in enzymatic assays.
• Optimized N-His Tag: The inclusion of the N-terminal Histidine tag allows for easy detection using anti-His antibodies and efficient immobilization on Ni-NTA resins for protein-protein interaction studies.
• Superior Stability: Formulated in a specialized buffer system designed to maintain enzymatic integrity, our research chemicals are engineered to withstand multiple freeze-thaw cycles when stored under recommended conditions.
• High Compatibility: The protein is designed for seamless integration into modern laboratory setups, including high-throughput screening (HTS) and surface plasmon resonance (SPR) workflows.
• Human-Source Precision: As a recombinant human protein, it provides the biological relevance necessary for clinical modeling and diagnostic development that synthetic or non-human analogs cannot match.

4. Applications Across Industries

The versatility of Recombinant Human MAN2C1 protein (N-His) allows it to serve multiple high-impact sectors. In the pharmaceutical industry, it is utilized as a target for small molecule screening in oncology, as MAN2C1 overexpression is frequently linked to various malignancies. Diagnostic laboratories employ this protein as a biomarker standard for lysosomal storage diseases and other metabolic disorders. In academic research, it is a cornerstone for scientists studying the unfolded protein response (UPR) and intracellular trafficking. Furthermore, the biotechnology sector utilizes MAN2C1 in the development of glyco-engineered therapeutic proteins, ensuring that glycan profiles meet strict regulatory requirements for safety and efficacy.

5. Why Choose This Product

When you buy Recombinant Human MAN2C1 protein (N-His) from a trusted biochemical distributor, you are securing more than just a reagent; you are investing in experimental reliability. This product is backed by a robust supply chain and full compliance with international laboratory reagents standards. We understand the complexities of global logistics and provide comprehensive documentation to simplify local import/export processes. Trusted by leading research universities and pharmaceutical giants worldwide, our proteins deliver the precision required for high-impact studies. Our technical support team consists of experienced scientists ready to assist with protocol optimization, ensuring that our products meet the unique needs of your research project.

6. Brand Credibility and Assurance

Our commitment to excellence is reflected in our adherence to global quality management systems. We operate with a decade of experience in protein expression and purification, ensuring that every vial of Recombinant Human MAN2C1 protein (N-His) meets the exact specifications listed on the certificate of analysis. Our expertise extends to offering flexible scales, from microgram quantities for pilot studies to bulk amounts for industrial manufacturing. By partnering with a leading Recombinant Human MAN2C1 protein (N-His) supplier, you gain access to professional consultation and a product line backed by unparalleled brand assurance and prompt worldwide delivery.

7. Call to Action

Elevate your research and development projects with the precision of our high-purity Recombinant Human MAN2C1 protein (N-His). Whether you are investigating metabolic pathways or screening for novel anti-cancer agents, our team is ready to provide the high-quality reagents you need to succeed. Contact us today for a custom quote or to discuss bulk supply options for your facility. Trust in our expertise to power your next scientific breakthrough.

FAQ

What is the recommended storage for MAN2C1 protein?

For long-term stability, it should be stored at -80 degrees Celsius. Avoid repeated freeze-thaw cycles by creating single-use aliquots.

Is the N-His tag removable?

Our standard version features a non-cleavable N-His tag for stable detection. Custom versions with protease cleavage sites (such as Thrombin or TEV) are available upon request.

What is the typical concentration provided?

Most batches are supplied at a concentration of 0.2 to 1.0 mg/mL, depending on the specific lot and your project requirements.

Can this protein be used in cell-based assays?

Yes, it is suitable for use as a positive control in enzymatic assays or for addition to cell lysates to study N-glycan processing.